| First Name | Last | Notable Fame | Cause of Death | Drug Category | When | Age |
|---|
| Christopher Wiley | Antley | Horse jockey; 2-time Kentucky Derby winner | Overdose (clobenzorex, paroxetine, methamphetamine, carbamazepine) and trauma (accidental) | Prescription drugs | 2000 | 34 |
| Chet | Baker | Jazz musician and singer, trumpet player, guitarist | Accidental fall from hotel window; cocaine, heroin | Illegal drugs | 1988 | 59 |
| Michael Carl | Baze | Horse jockey | Overdose; cocaine, oxymorphone (accidental) | Mixed illegal and prescription drugs | 2011 | 24 |
| Steven Scott | Bechler | Major League baseball pitcher; Baltimore Orioles | Heat stroke exacerbated by ephedra | Alternative/herbal drug | 2003 | 23 |
| Art | Bell | American broadcaster and author | Accidental overdose from prescription drugs including oxycodone, hydrocodone, diazepam, and carisoprodol | Prescription drugs | 2018 | 72 |
| John | Belushi | American actor; comedian; musician; Saturday Night Live comedy TV show | Speedball overdose; a combination of heroin and cocaine (accidental) | Illegal drugs | 1982 | 33 |
| George | Best | Professional soccer player | Complications due to alcohol abuse, alcoholism | Alcohol | 2005 | 59 |
| Len | Bias | Boston Celtics second overall NBA draft pick (1986) | Cardiac arrhythmia induced by a cocaine overdose (accidental) | Illegal drug | 1986 | 23 |
| Scott Charles "Bam Bam" | Bigelow | American professional wrestler; World Wrestling Federation (WWF) and World Championship Wrestling (WCW) | Multiple drug overdose: cocaine, temazepam (accidental), possibly worsened by heart disease | Mixed illegal and prescription drugs | 2007 | 45 |
| Erica | Blasberg | American golfer (LPGA) | Asphyxia; multiple drug overdose: butalbital, temazepam, alprazolam, codeine, hydrocodone, and tramadol (suicide) | Prescription drugs | 2010 | 25 |
| Jon | Bonham | English musician (drummer) and songwriter (Led Zeppelin) | Asphyxiation due to massive alcohol consumption | Alcohol | 1980 | 32 |
| Derek | Boogaard | Canadian professional ice hockey player; left wing (New York Rangers) | Alcohol and oxycodone overdose (accidental) | Mixed alcohol and prescription drugs | 2011 | 28 |
| Christopher | Bowman | American figure skater | Drug overdose: cocaine, diazepam, cannabis, alcohol (accidental) | Mixed alcohol, illegal, and prescription drugs | 2008 | 40 |
| Elisa | Bridges | American model, actress | Drug overdose: heroin, methamphetamine, alprazolam, meperidine | Mixed illegal and prescription drugs | 2002 | 28 |
| Lenny | Bruce | American comedian | Drug overdose: morphine (accidental) | Illegal drugs | 1966 | 40 |
| Richard | Burton | Welsh-born actor | Cerebral hemorrhage; possible complications due to alcohol, alcoholism | Alcohol | 1984 | 58 |
| Truman | Capote | American writer | Liver disease complicated by phlebitis, alcohol, and multiple drug intoxication | Alcohol | 1984 | 59 |
| Kurt | Cobain | American singer-songwriter and musician (Nirvana) | Gunshot wound to head; heroin and diazepam found in body (suicide) | Mixed illegal and prescription drugs | 1994 | 27 |
| Douglas Glenn "Dee Dee Ramone" | Colvin | American songwriter and musician (The Ramones) | Heroin overdose (accidental) | Illegal drug | 05 June 2002 | 50 |
| David | Croudip | American football defensive cornerback for the Atlanta Falcons | Cocaine overdose (accidental) | Illegal drug | 1988 | 30 |
| Tommy | Dorsey | American jazz musician | Choked himself while sleeping; unable to awaken due to sedative use | Prescription drug overdose | 1956 | 51 |
| Anthony | Durante | Professional wrestler | Oxycodone or fentanyl overdose (accidental) | Prescription drug overdose | 2003 | 36 |
| John | Entwistle | English bass guitarist (The Who) | Heart attack induced by cocaine | Illegal drug | 2002 | 58 |
| Howie | Epstein | American bass guitarist (Tom Petty and the Heartbreakers) | Possible heroin overdose; also reportedly using prescription antibiotics | Illegal drug overdose | 2003 | 47 |
| Brian | Epstein | English businessman; manager (The Beatles) | Sedative overdose (accidental) | Prescription drug overdose | 1967 | 32 |
| Chris | Farley | Comedian, actor; Saturday Night Live sketch comedy TV show | Overdose; combination of morphine and cocaine; complicated by heart disease; fluoxetine also in system (accidental) | Illegal drugs | December 1997 | 33 |
| Pete | Farndon | English bassist and founding member of the rock band the Pretenders | Heroin overdose | Illegal drug | 14 April 1983 | 30 |
| Edward "Umaga" | Fatu | Samoan-American professional wrestler | Hydrocodone, carisoprodol, diazepam (accidental) | Prescription drug overdose | 2009 | 36 |
| José | Fernández | Cuban-American professional baseball pitcher (Miami Marlins) | Boating accident while under the influence of cocaine and alcohol | Illegal drug and alcohol | 2016 | 24 |
| Sigmund | Freud | Neurologist | Physician-assisted suicide; morphine | Prescription drug overdose | 1939 | 83 |
| Judy | Garland | American actress and singer | Barbiturate (Seconal) overdose; controversial if suicide or accident | Prescription drug overdose | 22 June 1969 | 47 |
| Peaches | Geldof | English columnist, television personality, and model | Heroin overdose | Illegal drug | 2014 | 25 |
| Paul | Gray | bassist for the metal band Slipknot | overdose | morphine and fentanyl | 2010 | 38 |
| Eddie | Guerrero | Professional wrestler | Cardiomyopathy, heart disease, possibly due to anabolic steroid use | Anabolic steroids (speculated) | 2005 | 38 |
| Jeff | Hanneman | Musician (Slayer) | Cirrhosis due to alcoholism | Alcohol | 2013 | 49 |
| Paul | Hayward | Professional Rugby League Player; Newton Jets (Australia) | Heroin overdose; contracted HIV in prison | Illegal drug overdose | 1992 | 38 |
| Margeaux | Hemingway | American actress | Phenobarbital overdose; suicide | Prescription drug overdose | 1996 | 42 |
| Jimi | Hendrix | American musician and singer-songwriter | Respiratory arrest, asphyxia due to alcohol and barbiturate overdose; vomit inhalation | Mixed alcohol and prescription drugs | 1970 | 27 |
| Jarad "Juice WRLD" | Higgins | American rapper, singer, and songwriter | Overdosed on Percocet pills in an attempt to hide them from the police while conducting a search on his plane | Prescription drugs | 2019 | 21 |
| Philip Seymour | Hoffman | Actor | Acute mixed drug intoxication including heroin, cocaine, benzodiazepines, and amphetamine | Mixed illegal and prescription drugs | February 2014 | 46 |
| Abbie | Hoffman | American Political activist | Phenobarbital overdose (suicide) | Prescription drug overdose | 1989 | 52 |
| Billy | Holiday | American jazz singer and songwriter | Cirrhosis of the liver due to alcohol; alcoholism | Alcohol | 1959 | 44 |
| Whitney | Houston | American singer, actress | Drowning; complications of cocaine and heart disease; Flexeril, marijuana, Xanax, and Benadryl also found in body but did not contribute to death | Illegal drug | 2012 | 48 |
| Howard | Hughes | American business tycoon, movie producer and director, aviator, engineer, investor | Kidney failure; possible complications due to chronic use of aspirin (high doses) and dehydration | Nonprescription drug (not confirmed) | 1976 | 70 |
| Phyllis | Hyman | American singer, songwriter, and actress | Fatal overdose of pentobarbital and secobarbital (suicide) | Prescription drugs | 1995 | 45 |
| Andy | Irons | Surfer | Cardiac arrest complicated by mixed drug ingestion (cocaine, methamphetamine, alprazolam, methadone) | Mixed illegal and prescription drugs | 2010 | 32 |
| Michael | Jackson | American Pop Singer and icon | Cardiac arrest, acute propofol intoxication; midazolam, lidocaine, diazepam, lorazepam also noted in autopsy report | Prescription drugs | 25 June 2009 | 50 |
| Peter | Jackson | Australian rugby player | Heroin overdose (suicide) | Illegal drug | 1997 | 33 |
| Brian | Jones | Musician (The Rolling Stones) | Drowning due to alcohol and drug intoxication | unknown | 1969 | 27 |
| Janis | Joplin | American musician | Heroin overdose | Illegal drug | 04 October 1970 | 27 |
| Chris | Kelly | Rapper (Kris Kross) | Fatal overdose, cocaine, and heroin | Illegal drug | 2013 | 34 |
| Lisa Robin | Kelly | Actress (That '70s Show) | Multiple drug intoxication | Illegal drug | 15 August 2013 | 43 |
| David | Kennedy | Fourth son of Robert F. Kennedy; no profession | Overdose of cocaine, meperidine, thioridazine (controversial, some say he was murdered) | Mixed illegal and prescription drugs | 1984 | 28 |
| Jack | Kerouac | Author | Cirrhosis of liver, internal bleeding due to alcohol use | Alcohol | 1969 | 47 |
| John | Kordic | Professional hockey player | Lung failure complicated by unspecified drug overdose (possible anabolic steroid abuse) | unknown | 1992 | 27 |
| Joan "Chyna" | Laurer | American professional wrestler | Accidental overdose of alcohol and prescription drugs including diazepam, oxycodone, oxymorphone, and temazepam | Prescription drugs and alcohol | 20 April 2016 | 46 |
| Heath | Ledger | Australian actor | Combined drug toxicity due to oxycodone, hydrocodone, alprazolam, diazepam, temazepam, doxylamine (accidental) | Prescription drug overdose | 22 January 2008 | 28 |
| Bruce | Lee | Martial artist, actor, film director, pop culture icon | Cerebral edema due to meprobramate, aspirin | Prescription drug overdose | 1973 | 32 |
| Eugene "Big Daddy" | Lipscomb | Football defensive lineman in the National Football League (US), Pittsburgh Steelers; professional wrestler | Heroin overdose (accidental) | Illegal drug | 1963 | 31 |
| Chris | Mainwaring | Australian Football Player | Cocaine overdose (accidental) | Illegal drug | 2007 | 41 |
| Billy | Mays | Spokesperson | Heart disease possibly complicated by cocaine use | Illegal drug | 2009 | 51 |
| Joseph | McCarthy | U.S. Senator | Hepatitis exacerbated by alcohol, alcoholism | Alcohol | 1957 | 48 |
| Michelle | McNamara | author of the New York Times bestseller "I’ll Be Gone in the Dark" and wife of the comedian Patton Oswalt | effects of several drugs, including fentanyl, Xanax, and Adderall | Heart failure; drug-related (accidental) | 21 April 2016 | 46 |
| Mac | Miller | American rapper, singer, and record producer | Accidental overdose of fentanyl, cocaine, and alcohol | Prescription drugs and alcohol | September 2018 | 26 |
| Marilyn | Monroe | American actress, model, singer, sex symbol | Barbiturate overdose (suicide) | Prescription drug | 1962 | 36 |
| Cory | Monteith | Actor (Glee) and singer | Toxic mix of heroin and alcohol | Illegal drug and alcohol | July, 2013 | 31 |
| Keith | Moon | Drummer (The Who) | Clomethiazole overdose | Prescription drug | 1978 | 32 |
| Jim | Morrison | Musician, singer, songwriter (The Doors) | Heart failure; possible heroin or cocaine overdose (disputed) | Illegal drug | 1971 | 27 |
| Dolores | O'Riordan | Irish musician, singer, and songwriter (The Cranberries) | Accidental drowning due to alcohol intoxication | Alcohol | 2018 | 46 |
| Lil | Peep | American rapper and singer | Overdose of fentanyl and Xanax | Prescription drugs | 2017 | 21 |
| Tom | Petty | American singer and songwriter | Accidental overdose of prescription drugs including fentanyl and oxycodone | Prescription drugs | 02 October 2017 | 66 |
| River | Phoenix | American actor | Heroin and cocaine overdose | Illegal drugs | 31 October 1993 | 23 |
| Darrell | Porter | American professional baseball player | Cocaine overdose (accident) | Illegal drug | 2002 | 50 |
| Elvis | Presley | American musician, singer, actor, cultural icon | Heart arrhythmia, possibly aggravated by multiple prescriptions (methaqualone, codeine, barbiturates, cocaine), speculated | Mixed illegal and prescription drugs, speculated | 16 August 1977 | 42 |
| Freddie | Prinze | Actor | Self-inflicted gunshot; possibly under influence of methaqualone, cocaine (suicide) | Mixed illegal and prescription drugs, speculated | 1977 | 22 |
| John Simon "Sid Vicious" | Ritchie | Musician (Sex Pistols) | Heroin overdose (suicide) | Illegal drug | 1979 | 21 |
| Joan | Rivers | Actress | Therapeutic complication with propofol sedation | Prescription drugs | 2014 | 81 |
| Don | Rogers | Football safety in the National Football League (US), Cleveland Browns | Fatal cocaine overdose (accidental) | Illegal drug | 1986 | 23 |
| Hillel | Slovak | founding guitarist of the rock band Red Hot Chili Peppers | Heroin overdose | Illegal drug | 25 June 1988 | 47 |
| Anna Nicole | Smith | American model, television personality, actress, Playboy playmate | Accidental overdose: Combined drug toxicity of chloral hydrate, lorazepam, and diazepam | Prescription drugs | 08 February 2007 | 39 |
| Layne | Staley | American musician, songwriter, and the original lead singer of the rock band Alice in Chains | Cocaine and heroin | Illegal drug | 05 April 2002 | 34 |
| Verne | Troyer | American actor (Mini-Me in the Austin Powers film series) | Suicide by alcohol poisoning | Alcohol | 2018 | 49 |
| Ike | Turner | Musician, bandleader, songwriter, producer | Cardiovascular, lung disease complicated by cocaine overdose (accidental) | Illegal drug | 2007 | 76 |
| David | Waymer | American football player, NFL | Heart attack, cocaine related | Illegal drug | 1993 | 34 |
| Scott | Weiland | American musician, singer, and songwriter | Accidental overdose of cocaine, alcohol, and methylenedioxyamphetamine (MDA) | Illegal drugs and alcohol | 2015 | 48 |
| Logan | Williams | Actor on The CW's "The Flash," | unintentional illicit drug toxicity | fentanyl | 02 April 2020 | 17 |
| Michael K. | Williams | American Primetime Emmy Award nominated actor | fentanyl, p-fluorofentanyl, heroin, and cocaine | Illegal drug | 06 September 2021 | 54 |
| Hank | Williams, Sr. | Country music singer-songwriter | Heart failure, possibly alcohol, drug-related (accidental) | Mixed alcohol and Illegal drugs (speculated) | 1953 | 29 |
| Amy | Winehouse | English singer and songwriter | Fatal alcohol poisoning; alcoholism | Alcohol | 2011 | 27 |
| Prince | | American singer and songwriter | Accidental fentanyl overdose | Prescription drug | 2016 | 57 |
| First Name | Last | Notable Fame | Cause of Death | Drug Category | When | Age |
|---|